AUGUSTUS RADCLIFFE GROTE

Cecil Augustus Joll

Augustus Desiré Waller (1856-1922).

The electrocardiograph is one of the most important instruments with which to examine the human heart and is in constant use all over the world, yet we doubt whether many physicians know who was the first man to demonstrate that the electrical response accompanying the movement of the human heart could easily be shown by a clinical application of a relatively simple instrument. In the early par...

AUGUSTUS: ab initio prediction of alternative transcripts

AUGUSTUS is a software tool for gene prediction in eukaryotes based on a Generalized Hidden Markov Model, a probabilistic model of a sequence and its gene structure. Like most existing gene finders, the first version of AUGUSTUS returned one transcript per predicted gene and ignored the phenomenon of alternative splicing. Herein, we present a WWW server for an extended version of AUGUSTUS that ...

Grote, Johnston, Rakos, and Wulfert

The previous issue of this journal included my article entitled ''An Academic Home for a Natural Science," followed by the critical reactions of four prominent authors. In this article I respond to a number of the issues that they raised and further explicate my thesis.

Stepwise Enabling of AUGUSTUS for MediGRID

In the past years researchers from many domains have discovered Grid technology as it opens up new possibilities to solve more complex problems than with traditional cluster computing. In this report we examine the process to enable the life science application AUGUSTUS for execution inMediGRID. The gridification process starts with providing the security requirements and running the applicatio...